The academic research and those involving the clinical decisions making are presented on juxtaposed form in health-care providers’ practice, demand improvements and specialization of new necessary abilities to the professionals of information. Starting from this premise, we decide to investigate in the literature the publications in the areas that dealt, at the same time, with the thematic ones: Evidence-Based Medicine and Information Literacy. The objective of this work was to concept Evidence-Based Medicine and Information Literacy through literature revision and to designate the confluence of these thematic ones in health care providers’ practice. As a result of this analysis, it was verified that the professional of information needs to know the users, how the information is organized and how it presents itself, to get better search results, to reduce uncertainties and at the same time to provide to these researchers a bigger support for decision making. It was concluded that a demand for information needs directly that the professional of information applies the ability to take care appealing it to both qualification and knowledge to get to the suitable information, using the correct tools, answering the demand without leaving trustworthiness doubts. This professional, as a mediator, contributes very much for the practice of the Evidence-Based Medicine and the spreading of services and accesses to it as well as education and promotion.