Transversal–Longitudinal Pathogenetic Theory (TLPT)

Stroe, Petrica Transversal–Longitudinal Pathogenetic Theory (TLPT)., 2026 (Unpublished) [Report]

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English abstract

The Transversal–Longitudinal Pathogenetic Theory (TLPT) proposes a unified conceptual model describing the architecture, dynamics, and progression of human pathology through transversal and longitudinal network interactions. TLPT integrates 12 master-switch nodes (Nrf2, NF‑κB/NLRP3, AMPK, SIRT1, mTOR, HIF‑1α, SCFA–GPR, AhR, NO/eNOS, GLP‑1, TGF‑β, PPAR) into a coherent pathogenetic framework that explains attractor formation, meta-attractor dynamics, transversal fluxes, longitudinal progression, and universal pathogenetic rules. The theory introduces the Transversal Protector Meta-Attractor (MATP), the Universal Pathogenetic Pyramid, and a revised set of transversal–longitudinal criteria for network stability, resilience, and disease emergence. TLPT aims to provide a generalizable systems biology model applicable across diverse pathological contexts, offering a transversal–longitudinal perspective on disease mechanisms and protective network architectures.

Item type: Report
Keywords: Transversal pathogenetic architecture; Longitudinal progression; Molecular biology; Systems biology; Biopharmacology.
Subjects: L. Information technology and library technology
L. Information technology and library technology > LZ. None of these, but in this section.
Depositing user: Mr. Petrica Stroe
Date deposited: 24 Jul 2026 06:39
Last modified: 24 Jul 2026 06:39
URI: http://hdl.handle.net/10760/47943

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